Results
| PMID | 22392487 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | VEGF (+936TC, -460CT, +405CG, -2578AC, -1154GA) |
| Population size | 11 |
| Population details | 11 studies |
| Sex | Female |
| Associated genes | VEGF |
| Other associated phenotypes |
Endometriosis |
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Arch Gynecol Obstet. 2012 Jul;286(1):139-46. doi: 10.1007/s00404-012-2270-1. Epub Liang, Shoujun| Huang, Yin| Fan, Yujuan Guangxi Medical University, Nanning, Guangxi, People's Republic of China. PURPOSE: The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis. METHODS: By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated. RESULT: An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027-1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024-1.375, P = 0.023. Random-effect model: TT + TC vs. CC: OR 1.203, 95% CI 1.003-1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021-1.382, P = 0.026). No association between VEGF genes -460CT, +405CG, -2578AC, -1154GA polymorphisms and endometriosis was observed. CONCLUSION: Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not -460CT, +405CG, -2578AC, -1154GA. Mesh Terms: Endometriosis/*genetics| Female| Humans| *Polymorphism, Single Nucleotide| Risk Factors| Vascular Endothelial Growth Factor A/*genetics|DA 2012/12/12 06:00 |
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